Page 137 - 006
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131


                                                                            /



                            )

                                                  1
                         /


                   !  '  "          /"     5 '   !  .4    K !    H'* 3   #  
   
  *#
                                                                              )
                                                                    +/


                                                               +7
                   (conjugation) 
	##  ( !      K ' /    
 "3         !    HH

 *(  
  
   
 "5(
                                                                                 1

                                          7


                                                )


                      5   9
 "     "  *       ##    K     9
 "  oxidation 'L  0 C, N, S      P


                                                                                   /
                         &,   
 #   !  . 4    K   
* 
  7!   & #  % ("    
 !'* H
 reduce

                                                                                                   6/

                                                                                        )


                                                                                     /

                                                                              /
                   
 0      alkenyl, carboxyl    
 0      nitro 
 0     !  .4'   &   
 #    carboxyl

                                                                                  ,
                   * H)
     #  
   hydrolysis

                        8.3.2    4 "  #	$8 ;  % : ; $I%I    2 (Phase 2)
                                         /
                                         )

                                                            6


                                                                    )



                                !  .4'H
    /"  &  !      " 5 H
    /"  &  !    *  
   	 
#!  '        /
                                                                  )

                                                             71

                                                                    +7


                    ") - "      ,  .6/   & ! #    
      "  5(!     .4 (      !    H #H "



                                        0
                     
    
 "5(    "
   !   	7
                                ! /   %        ##   5  , +/ '1     ' / 
 /"     
	#
  " "!  "   !  .4'  " )



                                                                                                   /
                                                                 ,

                                                                                               /


                        
 " (xenobiotics)          5     5   
" 
#
  " "!  "!  .4'! &2 3
                                                                    /



                                                                                                1
                   %  ( &6  esterase, glutathione S-transferase     monooxygenase

                                1)  Esterase     
 0        5   *(!  .4 (detoxification  enzyme)


                                                                ,




                      5  '    	      
  " "!  "!  .4   9
 "  hydrolysis     
 0   ester,  amide


                          ,
                             /



                                     /
                                           ,
                       phosphate '     &   
 #   !  Q         5  ,  
 0    &    8.   (specific

                                                                                  7
                      6

                                                                               +/




                                                           /
                                                           1

                   enzyme)   
      	 
#!  .4     '! &2  
   *(.4      !  Q       
 0




                                                                           ,
                                                                                                ,
                                                                                                    )
                   organophosphate,  pyrethriod      chitin  inhibitor     5   esterase       5  ' "
                                                                                                  /

                    	7    
      /"      &  !      " ' / 1 (phase 1)  #    
     3 
 0  "  "(  "
	 5(
                                   - B-esterase 5(  
  aliesterase, carboxylesterase     cholinesterase
                                   - A-esterase 5(  
  arylesterase

                                   - 
 0   6/ K 5( 
 phosphatase,      phosphotriesterase,    amidase,

                   paraoxonase, malaoxonase

                                2)  Glutathione  S-transferase        5  '5  *  *  (non-specific
                                                                              ,
                                                                                 /


                                                               /
                                                             ,
                   enzyme)   
      	 
	#!  .4       5  ' "       
      /"      &  !     "
                                                                 )


                                                                    	7

                   ' / 2 (phase 2)  +/        5  '% "    9
 " 
  *# 
     !   reduced glutathione 
#






                                              ,
                                                /


                                            7
                                                   )

                   !  Q          5  ,%  (     "   ## (multiple form) 5( 
 aryl S-transferase, alkyl S-
                   transferase     epoxy S-transferase  ("&   !    H  
      /"      glutathione S-

                                                                                     /

                                                 1


                                         )

                   transferase 5(    "K    ## '   !    H       	 
#!  Q     '  &  !

                   
	 5(    "%  (5(  
  organophosphate, organochlorine, pyrethriod     carbamate
                                                                 ,


                                3)  Monooxygenase        5  '! &2% (   ' 
"    
# #


                                                                                     /

                                                                                   /
                                                                               +/
                                                                   1
                                                                   /
                                      	7
                                 +/
                                     )


                    1
                   '   "!  .4   "     
      /"      &  !     " ' / 1  (phase  1)   ("    9
 "





                   
      /"      &  !      !  .4'   !   
 "
 *(  
* 
   
 "  9
 " ! &2'               /
                                                                                                1





                                                                    1
                                                        /


                                                           )
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