Page 136 - 006
P. 136
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8.1.3 "P $ (Multiple resistant)
"H
' ! H! & ' ! Q
1
/
+
5
% % (
! & ' (" 3 1
. (
+/
6/
,
0
5 1 ! Q ( "
Y 5 ! H" "
! Q
!6/ N'L f 5(
( "
8.2 #;[## $"P : ; "_ $r_ : ; (Resistant mechanism)
!
5
' 5( " ##( 7
)
7
1
/
1.
! & ' ("
. % 5 # 3 1 ' ! Q
+ !) 5( %
2.
! & ' ("
/" .N
%
/" 5
.%
6
/
/
6
6
' ! Q ("
5 #
/" 5
'5 ! Q
3.
! & ' ("
! detoxification enzymes % " 9
"
+/
+7
" "! .4 % ! H! 5 ! ! (esterase) . 5 ,
,
+/
/
7
% ( * 5 " "! "! ' ! ' (ester bond) ! Q ' ! 5
,
/
1
7
7
1
.4
5 ("
5
! & ' ## #
5
! &2
! H ( 5 ,5( ( " & 6/ spectrophotometer GC
4.
! & ' (" . / & ( Y
#H " .6/ * (! . 4
'# (metabolism)
#
/" & ! ' % &
+
!
# K
" ! % (" 5 9
" ' .4 '"
/
,
/
'# #
'
/" & ! ! .4
*
' ! .4
+
1
/
&0 ! #
" 71 5( ( +7 " /" *
! .4'5 ! H
N'L f
(.4
6
/
/
6
! '
N'L f5(
/" ! .4'
N'L f .4 " 5 .4 "
6
(
8.3 # $ ; % $2!L823 8 ; % : ; Q $ $P (Detoxification)
/" & ! 2 7 &6
8.3.1 4 " # $8 ; % : ; $I%I 1 (Phase 1)
7
,
9
" " *
functional group
# &
#
/
6
! .4' ! hydrocarbon chain ring
/" ! & !
6
