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7.6.3 !F # $ =$IO 8 2!L (Calculation of toxicity value)
LD B,RM LC ' /
1 (
,LU54V&*A- ST ?'/ = 50 50 × 100
%+*,MM.P(Q' 2HM@+*,NO* >AC@(JK,L4 GHI*@3C*.
" %_
)
! Q carbosulfan .4 8 "#. '
(acute oral) LD
50
)
'
# 80 mg/kg .4 8 "#. ' 3 (acute dermal) '
# 2,250 mg/kg
carbosulfan ) Y( (granule; G) 5%
80
& . 4 8 "#. '
= × 100 = 160 mg/kg
5
7
8 ! 5( ! (#.4 carbosulfan & .4 8 "#. '
0
") ( #
(50-500 mg/kg)
, 2 250
& . 4 8 "#. ' 3 = × 100 = , 45 000 mg/kg
5
0
7
8 ! 5( ! (#.4 carbosulfan & .4 8 "#. '
3 ( # " (>1,000 mg/kg)
6/
+/
& LD ( " % &
.
! & % (
50
'*
% ' ( 'N4O
%! ,'( *
. !
1
1
/
'( "K ( !
V !( & H /
" %
6/
)
1
/
(! & ' % ( ' 7.3) !
5( % "
V * *
1
)
/
6
/
#! ,
"' /1
% 6/ K '( ' " % (! .4
Y
,
/
)
" *(
0 ' & 5
(hypersusceptible)
#
0 ' ' !
/
/
)
1
""
% !) *+ * ( .
' / & ' (resistance)
("
!
V ##& H /! ! * 5( ! & ## sigmoid ("&
logarithmic (' /1 !( ! ''
(.4
#! ## quantal ' "
1
+/
/
0
/
/
threshold dose H
* " %
##
(normal distribution)
/
4 ! & * Y ## sigmoid ' 9# *
"
'* .#
4 ##
7 6/ *
*1 " ' / % $+
4 5
. ' /* '1 5(
*
* ##
/
6/
L
&1 & LD
.
. /" ' ! & sigmoid
+7
)
50
V ! ( ) ' / 7.3) / *
%response 5 & probit unit *
+/
) L
#! ' 50% * & '
# 5 probit ! H&1 & LD 5( ("
/
7
50
